Publications

A selection of recent and significant publications can be viewed below.

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Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly.
Li Q, Pène V, Krishnamurthy S, Cha H, Liang TJ.
Nat Med (2013 Jun) 19:722-9. Abstract/Full Text
Current and future therapies for hepatitis C virus infection.
Liang TJ, Ghany MG.
N Engl J Med (2013 May 16) 368:1907-17. Abstract/Full Text
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ, Liang TJ.
Sci Transl Med (2015 Apr 8) 7:282ra49. Abstract/Full Text
Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.
Cheng X, Uchida T, Xia Y, Umarova R, Liu CJ, Chen PJ, Gaggar A, Suri V, Mücke MM, Vermehren J, Zeuzem S, Teraoka Y, Osawa M, Aikata H, Tsuji K, Mori N, Hige S, Karino Y, Imamura M, Chayama K, Liang TJ.
J Clin Invest (2020 Jun 1) 130:3205-3220. Abstract/Full Text
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1.
Hu Z, Rolt A, Hu X, Ma CD, Le DJ, Park SB, Houghton M, Southall N, Anderson DE, Talley DC, Lloyd JR, Marugan JC, Liang TJ.
Cell Chem Biol (2020 Jul 16) 27:780-792.e5. Abstract/Full Text

Additional Publications

Risk Factors for Delta Hepatitis in a North American Cohort: Who Should Be Screened?
Da BL, Rahman F, Lai WC, Kleiner DE, Heller T, Koh C.
Am J Gastroenterol (2021 Jan 1) 116:206-209. Abstract/Full Text
HLA-B*35:01 and Green Tea Induced Liver Injury.
Hoofnagle JH, Bonkovsky HL, Phillips EJ, Li YJ, Ahmad J, Barnhart H, Durazo F, Fontana RJ, Gu J, Khan I, Kleiner DE, Koh C, Rockey DC, Seeff LB, Serrano J, Stolz A, Tillmann HL, Vuppalanchi R, Navarro VJ, Drug-Induced Liver Injury Network..
Hepatology (2020 Sep 5) Abstract/Full Text
A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma.
Liu J, Tang W, Budhu A, Forgues M, Hernandez MO, Candia J, Kim Y, Bowman ED, Ambs S, Zhao Y, Tran B, Wu X, Koh C, Surana P, Liang TJ, Guarnera M, Mann D, Rajaure M, Greten TF, Wang Z, Yu H, Wang XW.
Cell (2020 Jul 23) 182:317-328.e10. Abstract/Full Text
Is SARS-CoV-2 Also an Enteric Pathogen With Potential Fecal-Oral Transmission? A COVID-19 Virological and Clinical Review.
Ding S, Liang TJ.
Gastroenterology (2020 Jul) 159:53-61. Abstract/Full Text
Coronavirus Disease-19 Has Come Home to Roost in Gastroenterology.
Koh C, Liang TJ.
Gastroenterology (2020 Jul) 159:36-38. Abstract/Full Text
Vibration-controlled transient elastography for the detection of cirrhosis in chronic hepatitis D infection.
Da BL, Surana P, Takyar V, Kleiner DE, Heller T, Koh C.
J Viral Hepat (2020 Apr) 27:428-436. Abstract/Full Text
United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.
Oketch-Rabah HA, Roe AL, Rider CV, Bonkovsky HL, Giancaspro GI, Navarro V, Paine MF, Betz JM, Marles RJ, Casper S, Gurley B, Jordan SA, He K, Kapoor MP, Rao TP, Sherker AH, Fontana RJ, Rossi S, Vuppalanchi R, Seeff LB, Stolz A, Ahmad J, Koh C, Serrano J, Low Dog T, Ko R.
Toxicol Rep (2020) 7:386-402. Abstract/Full Text
The Delta-4 fibrosis score (D4FS): A novel fibrosis score in chronic hepatitis D.
Da BL, Surana P, Kleiner DE, Heller T, Koh C.
Antiviral Res (2020 Feb) 174:104691. Abstract/Full Text
Chronic hepatitis delta: A state-of-the-art review and new therapies.
Gilman C, Heller T, Koh C.
World J Gastroenterol (2019 Aug 28) 25:4580-4597. Abstract/Full Text
Longitudinal effects of Nucleos(t)ide analogue therapy in chronic hepatitis B patients and the utility of non-invasive fibrosis markers during treatment: A single-center experience for up to 17 years.
Surana P, Kapuria D, Broadwell C, Wright EC, Takyar V, Kleiner DE, Ghany MG, Ben-Yakov G, Heller T, Liang TJ, Koh C.
Antiviral Res (2019 Aug) 168:61-67. Abstract/Full Text
Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122.
Lowey B, Hertz L, Chiu S, Valdez K, Li Q, Liang TJ.
mBio (2019 Jul 30) 10. Abstract/Full Text
Hepatic Manifestations of Cystic Fibrosis.
Sakiani S, Kleiner DE, Heller T, Koh C.
Clin Liver Dis (2019 May) 23:263-277. Abstract/Full Text
17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease.
Ma Y, Belyaeva OV, Brown PM, Fujita K, Valles K, Karki S, de Boer YS, Koh C, Chen Y, Du X, Handelman SK, Chen V, Speliotes EK, Nestlerode C, Thomas E, Kleiner DE, Zmuda JM, Sanyal AJ, (for the Nonalcoholic Steatohepatitis Clinical Research Network)., Kedishvili NY, Liang TJ, Rotman Y.
Hepatology (2019 Apr) 69:1504-1519. Abstract/Full Text
A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.
Koh C, Dubey P, Han MAT, Walter PJ, Garraffo HM, Surana P, Southall NT, Borochov N, Uprichard SL, Cotler SJ, Etzion O, Heller T, Dahari H, Liang TJ.
Antiviral Res (2019 Mar) 163:149-155. Abstract/Full Text
Development of Direct-acting Antiviral and Host-targeting Agents for Treatment of Hepatitis B Virus Infection.
Xia Y, Liang TJ.
Gastroenterology (2019 Jan) 156:311-324. Abstract/Full Text
Pathogenesis of and New Therapies for Hepatitis D.
Koh C, Heller T, Glenn JS.
Gastroenterology (2019 Jan) 156:461-476.e1. Abstract/Full Text
TM6SF2 Promotes Lipidation and Secretion of Hepatitis C Virus in Infected Hepatocytes.
Boyer A, Park SB, de Boer YS, Li Q, Liang TJ.
Gastroenterology (2018 Dec) 155:1923-1935.e8. Abstract/Full Text
Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.
Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang TJ.
J Virol (2018 Oct 1) 92. Abstract/Full Text
Spleen and Liver Volumetrics as Surrogate Markers of Hepatic Venous Pressure Gradient in Patients With Noncirrhotic Portal Hypertension.
Etzion O, Takyar V, Novack V, Gharib AM, Canales R, Adebogun A, Matsumoto E, Eccleston JL, Kleiner DE, Rosenzweig SD, Gunay-Aygun M, Uzel G, Fuss I, Childs R, Holland SM, Levy EB, Liang TJ, Heller T, Koh C.
Hepatol Commun (2018 Aug) 2:919-928. Abstract/Full Text
Association of Hepatic Steatosis With Subclinical Atherosclerosis: Systematic Review and Meta-Analysis.
Kapuria D, Takyar VK, Etzion O, Surana P, O'Keefe JH, Koh C.
Hepatol Commun (2018 Aug) 2:873-883. Abstract/Full Text
Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
Rolt A, Le D, Hu Z, Wang AQ, Shah P, Singleton M, Hughes E, Dulcey AE, He S, Imamura M, Uchida T, Chayama K, Xu X, Marugan JJ, Liang TJ.
J Infect Dis (2018 May 5) 217:1761-1769. Abstract/Full Text
Liver disease in patients with cystic fibrosis.
Kamal N, Surana P, Koh C.
Curr Opin Gastroenterol (2018 May) 34:146-151. Abstract/Full Text
Optimizing lonafarnib treatment for the management of chronic delta hepatitis: The LOWR HDV-1 study.
Yurdaydin C, Keskin O, Kalkan Ç, Karakaya F, Çalişkan A, Karatayli E, Karatayli S, Bozdayi AM, Koh C, Heller T, Idilman R, Glenn JS.
Hepatology (2018 Apr) 67:1224-1236. Abstract/Full Text
Hepatitis C in Injection-Drug Users - A Hidden Danger of the Opioid Epidemic.
Liang TJ, Ward JW.
N Engl J Med (2018 Mar 29) 378:1169-1171. Abstract/Full Text
N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly.
Schweitzer CJ, Zhang F, Boyer A, Valdez K, Cam M, Liang TJ.
J Virol (2018 Jan 15) 92. Abstract/Full Text
Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.
Cheng X, Xia Y, Serti E, Block PD, Chung M, Chayama K, Rehermann B, Liang TJ.
Hepatology (2017 Dec) 66:1779-1793. Abstract/Full Text
Cellular microRNA networks regulate host dependency of hepatitis C virus infection.
Li Q, Lowey B, Sodroski C, Krishnamurthy S, Alao H, Cha H, Chiu S, El-Diwany R, Ghany MG, Liang TJ.
Nat Commun (2017 Nov 27) 8:1789. Abstract/Full Text
Adult-onset cystic fibrosis liver disease: Diagnosis and characterization of an underappreciated entity.
Koh C, Sakiani S, Surana P, Zhao X, Eccleston J, Kleiner DE, Herion D, Liang TJ, Hoofnagle JH, Chernick M, Heller T.
Hepatology (2017 Aug) 66:591-601. Abstract/Full Text
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.
He S, Li K, Lin B, Hu Z, Xiao J, Hu X, Wang AQ, Xu X, Ferrer M, Southall N, Zheng W, Aubé J, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.
J Med Chem (2017 Jul 27) 60:6364-6383. Abstract/Full Text
Pharmacokinetics and pharmacodynamics modeling of lonafarnib in patients with chronic hepatitis delta virus infection.
Canini L, Koh C, Cotler SJ, Uprichard SL, Winters MA, Han MAT, Kleiner DE, Idilman R, Yurdaydin C, Glenn JS, Heller T, Dahari H.
Hepatol Commun (2017 Jun) 1:288-292. Abstract/Full Text
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ.
Gastroenterology (2017 May) 152:1297-1309. Abstract/Full Text
Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.
Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ.
J Hepatol (2017 Mar) 66:494-503. Abstract/Full Text
Complications of percutaneous liver biopsy with Klatskin needles: a 36-year single-centre experience.
Takyar V, Etzion O, Heller T, Kleiner DE, Rotman Y, Ghany MG, Fryzek N, Williams VH, Rivera E, Auh S, Liang TJ, Hoofnagle JH, Koh C.
Aliment Pharmacol Ther (2017 Mar) 45:744-753. Abstract/Full Text
Infection of Hepatocytes With HCV Increases Cell Surface Levels of Heparan Sulfate Proteoglycans, Uptake of Cholesterol and Lipoprotein, and Virus Entry by Up-regulating SMAD6 and SMAD7.
Zhang F, Sodroski C, Cha H, Li Q, Liang TJ.
Gastroenterology (2017 Jan) 152:257-270.e7. Abstract/Full Text
Noninvasive markers for staging fibrosis in chronic delta hepatitis.
Takyar V, Surana P, Kleiner DE, Wilkins K, Hoofnagle JH, Liang TJ, Heller T, Koh C.
Aliment Pharmacol Ther (2017 Jan) 45:127-138. Abstract/Full Text
Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition.
Li Q, Sodroski C, Lowey B, Schweitzer CJ, Cha H, Zhang F, Liang TJ.
Proc Natl Acad Sci U S A (2016 Jul 5) 113:7620-5. Abstract/Full Text
Experimental models of hepatitis B and C - new insights and progress.
Thomas E, Liang TJ.
Nat Rev Gastroenterol Hepatol (2016 Jun) 13:362-74. Abstract/Full Text
Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant.
Li J, Woods SL, Healey S, Beesley J, Chen X, Lee JS, Sivakumaran H, Wayte N, Nones K, Waterfall JJ, Pearson J, Patch AM, Senz J, Ferreira MA, Kaurah P, Mackenzie R, Heravi-Moussavi A, Hansford S, Lannagan TRM, Spurdle AB, Simpson PT, da Silva L, Lakhani SR, Clouston AD, Bettington M, Grimpen F, Busuttil RA, Di Costanzo N, Boussioutas A, Jeanjean M, Chong G, Fabre A, Olschwang S, Faulkner GJ, Bellos E, Coin L, Rioux K, Bathe OF, Wen X, Martin HC, Neklason DW, Davis SR, Walker RL, Calzone KA, Avital I, Heller T, Koh C, Pineda M, Rudloff U, Quezado M, Pichurin PN, Hulick PJ, Weissman SM, Newlin A, Rubinstein WS, Sampson JE, Hamman K, Goldgar D, Poplawski N, Phillips K, Schofield L, Armstrong J, Kiraly-Borri C, Suthers GK, Huntsman DG, Foulkes WD, Carneiro F, Lindor NM, Edwards SL, French JD, Waddell N, Meltzer PS, Worthley DL, Schrader KA, Chenevix-Trench G.
Am J Hum Genet (2016 May 5) 98:830-842. Abstract/Full Text
Virology: The X-Files of hepatitis B.
Liang TJ.
Nature (2016 Mar 17) 531:313-4. Abstract/Full Text
Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ.
J Med Chem (2016 Feb 11) 59:841-53. Abstract/Full Text
Present and future therapies of hepatitis B: From discovery to cure.
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS.
Hepatology (2015 Dec) 62:1893-908. Abstract/Full Text
Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.
Hu Z, Hu X, He S, Yim HJ, Xiao J, Swaroop M, Tanega C, Zhang YQ, Yi G, Kao CC, Marugan J, Ferrer M, Zheng W, Southall N, Liang TJ.
Antiviral Res (2015 Dec) 124:20-9. Abstract/Full Text
Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial.
Koh C, Canini L, Dahari H, Zhao X, Uprichard SL, Haynes-Williams V, Winters MA, Subramanya G, Cooper SL, Pinto P, Wolff EF, Bishop R, Ai Thanda Han M, Cotler SJ, Kleiner DE, Keskin O, Idilman R, Yurdaydin C, Glenn JS, Heller T.
Lancet Infect Dis (2015 Oct) 15:1167-1174. Abstract/Full Text
Hepatic expression levels of interferons and interferon-stimulated genes in patients with chronic hepatitis C: A phenotype-genotype correlation study.
Noureddin M, Rotman Y, Zhang F, Park H, Rehermann B, Thomas E, Liang TJ.
Genes Immun (2015 Jul-Aug) 16:321-9. Abstract/Full Text
Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection.
Pène V, Li Q, Sodroski C, Hsu CS, Liang TJ.
J Virol (2015 May) 89:5462-77. Abstract/Full Text