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Peter Perrin, Ph.D.

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Gastrointestinal Host-Microbial Interactions, Basic Mucosal Immunology and Inflammation

Responsibilities & Activities

As a Program Director in the Division of Digestive Diseases and Nutrition, I support basic and translational research related to gastrointestinal immunology, microbial-host interactions, the response of the gut epithelium to inflammation, gastrointestinal transport and absorption, and the effects of HIV or its treatment within the gastrointestinal system. Research projects cover innate and adaptive gastrointestinal immunity; various aspects of mucosal inflammation and colitis; interactions between the gut microbiome and the host that promote homeostasis; pathogenic interactions between the microbiota and the host; approaches to inflammatory bowel disease and other diseases of the gastrointestinal tract with immune or infectious components; the involvement of the epithelium in pathogenic processes; transporter function in GI health and disease; lipid absorption and processing in the intestine; host response pathways in diarrheal diseases; effects of HIV or its treatment on the gastrointestianal immune system; HIV enteropathy and eptithelial barrier dysfunction; mechanisms of HIV infection, latency, and persistence in the gastrointestinal system; and research toward an HIV cure primarily focused on mechanisms within the gastrointestinal system. In my capacity as Digestive Diseases Research Cores Centers, I support shared resources (i.e., core facilities) with the goal of fostering interdisciplinary cooperation between investigators that conduct high quality research on digestive and liver diseases Finally, as NIDDK's AIDS research coordinator, I work with other staff across NIDDK to help coordinate the Institute's HIV-related research.

Research Programs

Digestive Diseases Research Core Centers
Bringing together basic and clinical investigators to enhance the impact of their digestive and/or liver diseases research.

Gastrointestinal Immunology, Inflammation, & Inflammatory Diseases
Research on mucosal immunology, intestinal immunity, and inflammation in gastrointestinal diseases and conditions.

Gastrointestinal Microbiology & Infectious Diseases
Research on the gut microbiota, pathogenic organisms that reside in the gastrointestinal tract.

Gastrointestinal Physiology, Development, & Epithelial Biology
Basic, clinical, and translational research on GI development, diseases, and disorders.

Committees & Working Groups

  • NIH AIDS Executive Committee, Member
  • NIH Human Microbiome Working Group, Member