Gastrointestinal Immunology, Inflammation, & Inflammatory Diseases
Research on mucosal immunology, intestinal immunity, and inflammation in gastrointestinal diseases and conditions.
The Gastrointestinal Immunology, Inflammation, and Inflammatory Diseases Program supports basic, clinical, and translational research on mucosal immunology, intestinal immunity, and inflammation in gastrointestinal diseases and conditions. In particular, the program supports research on differentiation of gut-associated lymphoid tissue, regulation of innate and adaptive immune cell differentiation and function, genetic and epigenetic factors regulating immune responses and inflammation, the role of dietary components and nutrients in mediating inflammatory responses, the mechanisms by which the intestinal microbiota interact with the mucosal immune system to regulate inflammation and contribute to inflammatory diseases, immune response to enteric infections and antigens, and interactions between the immune and epithelial compartments in the gastrointestinal tract. Translational research is encouraged to translate basic mechanisms regulating inflammation and the pathophysiology of inflammatory diseases into novel targets and therapeutic strategies for treating or preventing disease. This program also supports clinical research, clinical trials, and epidemiology studies on gastrointestinal inflammatory diseases, including, but not limited to, gluten-sensitive enteropathy, inflammatory bowel disease, and gastritis; malabsorption syndromes; diarrhea; gastric and duodenal ulcers; and disease of the salivary glands (excluding cystic fibrosis). The program also encourages epidemiology research to address risk factors for disease occurrence and disease prognosis or natural history, and it supports databases and biological repositories that advance clinical and epidemiological studies in digestive diseases and nutrition.
NIDDK Program Staff
- Frank Hamilton, M.D., M.P.H. Clinical Neurogastroenterology; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal Motility
- Peter Perrin, Ph.D. Gastrointestinal Host-Microbial Interactions, Basic Mucosal Immunology and Inflammation
- Robert W. Karp, Ph.D. Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and Obesity
- Terez Shea-Donohue, Ph.D. Basic and Translational Neurogastroenterology, Gastrointestinal Motility, Gastrointestinal Barrier Function, Mucosal Immunology and Inflammation
Recent Funding OpportunitiesView More Recent Funding Opportunities
Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed)
Notice of Special Interest: Development of Swallowable Smart Pills or Devices for Precision Nutrition, Microbiome and Digestive Disease Applications
Support of Competitive Research (SCORE) Pilot Project Award (SC2 - Clinical Trial Not Allowed)
Support of Competitive Research (SCORE) Research Advancement Award (SC1 - Clinical Trial Not Allowed)
HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Providing education and training for the next generation of biomedical and behavioral scientist
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