Gastrointestinal Microbiology & Infectious Diseases
Research on the gut microbiota, pathogenic organisms that reside in the gastrointestinal tract.
The Gastrointestinal Microbiology and Infectious Diseases program supports basic, clinical, and translational research on the gut microbiota, pathogenic organisms that reside in the gastrointestinal tract, and the host-microbial interactions that affect host physiology and the pathophysiology of digestive diseases and nutrition. In particular, the program focuses on research characterizing the structure and function of the intestinal microbiome; mechanisms by which organisms of the microbiome contribute to disease processes in the gastrointestinal tract; innate immunity and inflammation, barrier function and gut permeability; the interaction between diet and the microbiome as it relates to nutrient metabolism, energy balance and metabolic disease; impact of gut microbiome on the gut-brain axis, bile acid metabolism and characterization of the role of microbial metabolites in physiological functions; the host response to gastrointestinal infections, such as Helicobacter pylori, Clostridium difficile, pathogenic Escherichia coli, Vibrio cholera, and enteric viruses; and the interactions between the mucosal immune system and the intestinal microbiome to maintain normal homeostasis or imbalance leading to inflammation and disease pathophysiology.
NIDDK Program Staff
- Frank Hamilton, M.D., M.P.H. Clinical Neurogastroenterology; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal Motility
- Padma Maruvada, Ph.D. Nutrient Metabolism; Clinical Obesity and Nutrition
- Peter Perrin, Ph.D. Gastrointestinal Host-Microbial Interactions, Basic Mucosal Immunology and Inflammation
- Robert W. Karp, Ph.D. Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and Obesity
- Terez Shea-Donohue, Ph.D. Basic and Translational Neurogastroenterology, Gastrointestinal Motility, Gastrointestinal Barrier Function, Mucosal Immunology and Inflammation
Recent Funding OpportunitiesView More Recent Funding Opportunities
NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional)
NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required)
NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Multidisciplinary Studies of HIV/AIDS and Aging (R01 Clinical Trial Optional)
Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.
Providing education and training for the next generation of biomedical and behavioral scientist