About Our Research
The Section on Pediatric Diabetes, Obesity, and Metabolism conducts metabolic clinical trials to understand the complex association of biological, social, and environmental factors in the pathogenesis of pediatric diabetes, obesity, and metabolism. Type 2 diabetes is a leading cause of death and disability worldwide, especially in underrepresented minority groups. The transgenerational cycle of diabetes and the epidemic of childhood obesity are among the most important factors for type 2 diabetes development and contribute to a disproportionate burden of disease in youth and young adults. Moreover, current therapies for type 2 diabetes in youth are limited and response to metformin, the first-line agent in youth, is highly variable and insufficient in up to 50% of youth within 2 years of diagnosis. Current projects investigate factors associated with metformin treatment failure while evaluating innovative strategies and therapies to minimize disease burden in youth and young adults. Our long-term goals are to reduce diabetes-related health disparities across the lifespan by improving primary prevention of cardiometabolic disease. Specific interests include developing population-specific risk stratification paradigms and novel pharmacologic and pharmacogenetic targets in youth and young adults.