Work continued in 2021 despite the pandemic

Members of the Usdin Lab 2022: Bruce Hayward, Karen Usdin, Xiaonan Zhao, Daman Kumari, Diego Jimenez and Carson Miller.Typical weekly lab meeting in 2021 thanks to COVID-19.

Hot on the heels of our first efforts with gene knockouts (Carson!) and base-editing (Bruce!) using CRISPR-Cas9 technology in 2020 which demonstrated that all 3 MutL proteins were required for expansion and that the nuclease activity of MutLɣ was essential, Nan took things a step further using an in vivo CRISPR-Cas9 HDR approach to show that FAN1’s nuclease activity is required for its protection against repeat expansion.

The pandemic also gave us time to catch up with the literature and write some reviews:

Comings and Goings

July 2021

  • Diego Jimenez joined the lab as a Postbac IRTA. He is working with Dr. Xiaonan Zhao on the mechanism of repeat expansion in the Fragile X related disorders and Huntington’s disease. He is already indispensable.

April 2021

  • Dr. Grace Kim, who joined us in 2018, left us in April for a job as a research scientist with GlycoT Therapeutics. Good luck, Grace.
Photo of Grace Kim.
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