Clinical Trials
Open studies conducted by NIDDK Principal Investigators appear below. Study statuses may include the following:
- Open: Recruiting - Currently recruiting participants and open to everyone who meets eligibility criteria.
- Open: Active, Not Recruiting - Participants are receiving an intervention or being examined, however new participants are not being recruited or enrolled.
- Open: Enrolling by Invitation - People in a particular population were selected in advance and invited to participate. The study is not open to everyone who meets the eligibility criteria.
- Open: Available for Expanded Access - Patients who are not participants in the clinical study may be able to gain access to the drug, biologic, or medical device being studied.
Studies Seeking Patients
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Background:
Diet-induced thermogenesis (DIT) is the amount of energy one s body uses to eat food, absorb
the nutrients from the food, and process those nutrients. Researchers would like to
understand more about how changing the balances of protein, fat, carbohydrates, and total
calories in the diet can affect DIT.
Objective:
To learn how different diets can change a person s DIT.
Eligibility:
Healthy people aged 18 to 60 years who have not intentionally lost weight in the past 6
months.
Design:
Participants will stay in a clinic for about 34 days. They will eat only the food provided.
They will receive 8 different diets during the study, including 7 test diets.
Participants will undergo multiple tests.
They will be screened with blood and urine tests and a test of their heart function.
During the first few days:
Their waist, thigh, and neck circumference will be measured.
They will have a DXA scan: They will lie on a padded table for about 20 minutes while an
instrument measures the amount of fat in their body.
They will be tested for diabetes.
They will answer questionnaires about topics including eating behavior, hunger, and stress.
Throughout the study:
Their weight will be measured daily.
Blood tests will be repeated.
They will stay in a metabolic chamber a total of 9 times. They will remain in a closed room
for 24 hours while researchers monitor the room temperature and levels of oxygen and carbon
dioxide. Participants will collect all their urine for each 24-hour period.
...
The trial is Open with a status of Recruiting.
Investigator: Tomas Cabeza De Baca
Referral Contacts: Office of Participant Recruitment (NIDDK (602) 200-5315
The Impact of the COVID-19 Pandemic on Eating Behavior and Weight Change
Background:
The indirect effects of the COVID-19 pandemic on mental health are of increasing concern.
Perceived stress can lead to binge eating and weight gain. Researchers want to learn more
about the relationship between eating behavior and the pandemic.
Objective:
To study how the stress of the COVID-19 pandemic is affecting eating behaviors and weight.
Eligibility:
English-speaking adults ages 18 and older who have access to a computer or smartphone
connected to the internet.
Design:
This is an online study. Participants will answer surveys through the study website.
Participants will complete a one-time survey. It will ask about their experiences throughout
the COVID-19 pandemic, their socioeconomic standing, their mental and physical health, and
their eating habits. They will have the option to repeat the survey once a month for the next
12 months. This will show changes in their thoughts and behaviors over time. They will
provide their email address to get survey links.
Participants will also have the option to complete a 2-minute survey on their smartphone.
They will complete the survey daily for 7 days in a row. It will ask about their stress and
eating behavior in real time, in their home environment. They will provide their phone number
to get survey links via text message.
If a participant has taken part in a previous NIH study on the Phoenix AZ campus, they will
be asked to share their first and last name, date of birth, and email address. This
information will be used to connect data from this study to their past data.
Participation is typically 25 minutes but may last up to 1 year.
***To participate in this study go to the REDCap study link:
https://redcap.link/nihcovidstudy.***...
The trial is Open with a status of Active, not recruiting.
Investigator: Marci E Gluck, Ph.D.
Food Intake Response to Short-Term Modifications of Metabolism in Humans
One reason people gain weight is eating more calories from food than what they need for
energy over 24 hours. Metabolism is the amount of energy a person uses over 24 hours.
Researchers want to study the relationship between changes in metabolism and how much a
person eats.
Objectives:
To see how much food a person eats when the body's temperature is cooled. To study how
changes in metabolism may alter the amount of food a person eats.
Eligibility:
Healthy people ages 18-55.
Design:
Participants will stay at NIH for 20 days.
During the first 4 days, participants will have:
- Medical exam
- Electrocardiogram
- Blood and urine tests. One blood test includes drinking a sugar solution.
- DXA body composition scan
- Questions about foods they like, physical activity, and personal behavior
- Exercise test on a stationary bicycle
Participants will spend 24-hour periods in a metabolic chamber. The chamber will be at normal
room temperature or cooler.
Some times, participants will eat a diet that matches their daily needs. Other times, they
can eat as much as they wish from a vending machine.
Participants will have blood and urine collected.
Participants will swallow an ingestible wireless sensor and wear a small data recorder
device.
On the second to last day, participants will stay in the metabolic chamber but only consume
water and non-caffeinated sugar-free beverages.
Participants will come back for 1-day visits at six months and one year from the first
admission. They will have blood and urine tests, and a DXA scan. They will answer questions
on physical activity and food habits.
The trial is Open with a status of Recruiting.
Investigator: Douglas Chang, M.D.
Referral Contacts: Kat A Ware Not Listed
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
This study will determine whether electrical stimulation of an area of the brain called the
dorsolateral prefrontal cortex, which is important in determining the feeling of fullness
after eating, affects how much food a person eats and weight loss over 4 weeks. It will also
compare weight changes in people who attend weight loss counseling sessions and those who do
not over this period of time.
Obese, non-diabetic people between 18 and 60 years of age who are in good health and who live
in the Phoenix, AZ, metropolitan area are eligible for this study. Candidates must have a
body mass index of 35 kg/m(2) or more and weigh less than 350 pounds.
Participants are admitted to the NIH inpatient unit in Phoenix for the first 9 days of the
study for tests, which include meal tests to determine eating behaviors and caloric intake,
blood and urine tests, glucose tolerance test, weight measurement, psychological assessments
and DEXA scan to measure body fat. For 3 of the days, they will be asked to eat all of their
food from automated vending machines. Some subjects receive transcranial direct current
stimulation (TDCS). For this procedure, electrodes that conduct electricity are placed on the
head and arm and the current is turned on for 40 minutes. Some tingling may be felt under the
electrodes. Other subjects receive sham TDCS, with the current turned on only very briefly.
After the evaluations, subjects are discharged home from the NIH unit and instructed to eat
25 percent fewer calories than they consumed while on a weight maintenance diet the first 3
days of their inpatient stay. They maintain the lower calorie diet at home for 4 weeks.
During this period they come to the NIH unit 3 days a week to receive either real or sham
TDCS.
The trial is Open with a status of Recruiting.
Investigator: Marci E Gluck, Ph.D.
Referral Contacts: Kat A Ware (602) 200-5300
The Food Intake Phenotype: Assessing Eating Behavior and Food Preferences as Risk Factors for Obesity
The prevalence of obesity in the United States has reached alarming proportions with 33% of
adults over the age of 20 being overweight. Obesity is more than twice as prevalent, however,
in the Pima Indians of Arizona. Although there have been a number of advances in our
understanding of the genetics of obesity, the environmental influences on the genetic
expression of obesity requires further investigation.
In an effort to understand some of the influences on the high prevalence of obesity in the
Pima Indians, the present study was designed to investigate eating behaviors and food
preferences, most especially the preference for high fat foods, in sib-pairs of Pima Indians
who have been previously genotyped in our genomic scan for loci linked to diabetes/obesity.
Most specifically, we will utilize several questionnaires and methods of assessing eating
behavior and the preference for high fat foods to create a food intake phenotype. In
addition, we will study Caucasians so that comparisons can be made between these two groups.
We will make these evaluations by assessing eating behavior, food preferences including usual
fat intake and preferences for high fat foods, body image perceptions, and energy
expenditure. It is hoped that the data gathered from this study will elucidate some of the
risk factors for the development of obesity among the Pima Indians....
The trial is Open with a status of Recruiting.
Investigator: Susi M Votruba, Ph.D.
Referral Contacts: Kat A Ware (602) 200-5300
Last Reviewed November 2023