Catheter-Associated Urinary Tract Infections Technology Workshop

Event Details

Background

Catheter-associated urinary tract infections (CAUTIs) are the most common healthcare associated infection. Between 15-25% of hospitalized patients receive urinary catheters during their hospital stay, and prolonged use of a urinary catheter is a risk factor for developing a CAUTI. CAUTIs are responsible for increased morbidity and mortality (e.g., due to bloodstream infections), excess length of stay, increased cost, and unnecessary antimicrobial use. In addition to implementing clinical best practices to reduce CAUTIs, development of new catheter technologies is expected to have a significant clinical impact, thereby supporting NIH’s mission of seeking fundamental knowledge about the nature and behavior of living systems and applying that knowledge to enhance health, lengthen life, and reduce illness and disability.

Objectives

The purpose of the conference is to promote the development of new or improved technologies to reduce the incidence and severity of catheter-associated urinary tract infections. The workshop will attempt to achieve this goal through a review of the science, by highlighting basic research that may inform new technologies, by providing guidance to innovators on the development path, by identifying common hurdles and discussing proactive solutions, and by promoting interactions between constituents.

Registration Deadline

March 10, 2019

Agenda

March 11, 2019

8:00 – 8:45 a.m.

Welcome and Opening Remarks
Gregory G. Germino, M.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Meeting Overview
Daniel Gossett, Ph.D., NIDDK

Framing the Issues
Dirk Lange, Ph.D, The University of British Columbia

Session One: Development of New Technologies for CAUTI
Moderator: Ziya Kirkali, M.D., NIDDK

8:45 – 9:45 a.m.

FDA Regulatory Process for CAUTI Medical Devices: Premarket Review Processes, Expectations, and Challenges [Presentation 1: Haugen (PDF, 1.46 MB) ], [Presentation 2: Soler-García (PDF, 1.05 MB) ]
Shani Haugen, Ph.D., U.S. Food and Drug Administration (FDA)
Ángel A. Soler-García, Ph.D., U.S. Food and Drug Administration (FDA)

9:45 – 10:00 a.m.

Current ASTM Standards to Test Urinary Catheters
Dirk Lange, Ph.D., The University of British Columbia

10:00 – 10:30 a.m.

Proposed Standard Method for Testing the Efficacy of Antimicrobial Urinary Catheters [Presentation (PDF, 2.25 MB) ]
Elinor Pulcini, Ph.D., Montana State University

10:30 – 11:00 a.m.

Impact of CAUTI on an Integrated Health System
Reza Goharderakhshan, M.D., Kaiser Permanente

11:00 – 11:30 a.m.

Navigating Medicare [Presentation (PDF, 97.28 KB) ]
Susan Miller, M.D., Centers for Medicare & Medicaid Services

11:30 a.m – 12:00 p.m.

Developing a Value Proposition for Adoption of New Catheter Technology
Michelle Kim, M.D., Ph.D., Massachusetts General Hospital

12:00 – 1:00 p.m.

Lunch and Poster Session

Session Two: New Technological Approaches
Moderator: Dirk Lange, Ph.D., The University of British Columbia

1:00 – 1:30 p.m.

Bio-inspired Liquid-infused Surfaces for Reducing Bacterial Adhesion in Catheters [Presentation (PDF, 1.76 MB) ]
Caitlin Howell, Ph.D., University of Maine

1:30 – 2:00 p.m.

Antibiofilm Coatings for the Prevention of CAUTI
Jayachandran Kizhakkedathu, Ph.D., The University of British Columbia

2:00 – 2:30 p.m.

Flexible Microsystems-Integrated Urinary Catheters to Aid CAUTI Prevention[Presentation (PDF, 3.91 MB) ]
Reza Ghodssi, Ph.D., University of Maryland, College Park

2:30 – 3:00 p.m.

Ultra-low Fouling Zwitterionic Materials and Coatings
Shaoyi Jiang, Ph.D., University of Washington

3:00 – 3:30 p.m.

Design of Catheter Coatings for Localized Release of Antimicrobial Peptide Mimetics[Presentation (PDF, 2.9 MB) ]
Sean Palecek, Ph.D., University of Wisconsin—Madison

3:30 – 4:00 p.m.

An Effective Solution for the Prevention of Bacterial Load and CAUTI, Through the Application of Surface Acoustic Waves on Indwelling Catheters
Brian Murphy, NanoVibronix, Inc.

March 12, 2019

8:30 – 9:00 a.m.

Challenges in Clinical Translation [Presentation (PDF, 7.82 MB) ]
Jennifer Ann Meddings, M.D., University of Michigan Medical School

Session Three: Biology of CAUTI
Moderator: Christopher Mullins, Ph.D., NIDDK

9:00 – 9:30 a.m.

Pseudomonas Aeruginosa CAUTI [Presentation part 1 (PDF, 2.93 MB) ], [Presentation part 2 (PDF, 1.75 MB) ]
Vincent Lee, Ph.D., University of Maryland, College Park

9:30 – 10:00 a.m.

Proteus Mirabilis CAUTI: Impact of Polymicrobial Interactions [Presentation (PDF, 4.36 MB) ]
Chelsie Armbruster, Ph.D., University at Buffalo

10:00 – 10:30 a.m.

Urinary Catheterization: Microbial Window of Opportunities
Ana Flores-Mireles, Ph.D., University of Notre Dame

10:30 – 11:00 a.m.

Metal ion Tug of War in CAUTI
Jose Lemos, Ph.D., University of Florida

11:00 a.m. – 12:00 p.m.

Lunch

Session Four: Approaches in the Pipeline
Moderator: Daniel Gossett, Ph.D., NIDDK

12:00 – 12:30 p.m.

Nitric Oxide (NO) Releasing Urinary Catheters to Reduce the Risk of CAUTIs [Presentation (PDF, 4.19 MB) ]
Mark Meyerhoff, Ph.D., University of Michigan

12:30 – 1:00 p.m.

Antimicrobial Catheters with Cell and Tissue Compatibility [Presentation (PDF, 1.43 MB) ]
Kenneth Wynne, Ph.D., WynnVision LLC

1:00 – 1:30 p.m.

Innovative Catheter Design to Reduce CAUTI [Presentation (PDF, 534.04 KB) ]
Derek Herrera, Spinal Singularity

1:30 – 2:00 p.m.

A High-throughput Catheter Array System to Evaluate the Bacterial Interference Approach Against CAUTI
Chengzhi Cai, Ph.D., University of Houston

2:00 – 2:15 p.m.

Break

2:15 – 3:45 p.m.

Breakout Groups

3:45 – 4:45 p.m.

Breakout Group Reports

4:45 p.m.

Adjournment

Abstracts

Abstracts are invited for poster presentations. The poster session will be held in the Atrium during lunch on Day-1, March 11, 2019. Presenters are invited to leave posters up all-day March 11 but should remove them by 5:00 p.m. Space is limited, and the organizing committee may implement a selection process a breadth of meritorious research is presented.

Submission Deadline

March 1, 2019

Submitting Abstracts

All abstracts must be submitted via email to Danielle Johnikin of The Scientific Consulting Group, Inc. Abstract submissions should be no longer than 250 words (not including name and affiliation). Download the Abstract Template (DOCX, 24.16 KB)

Formatting Requirements

Please follow the instructions below to format an abstract. (Note: Submissions will not be edited for spelling or grammar and will be accepted “as is.”)

• The abstract should be an MS Word document typed single-spaced using Times New Roman font. Everything but the title should be in normal, 12-point font.
  • The abstract’s title should be Bold, 16-Point, Title Case font and should clearly represent the nature of the investigation.
  • On the line after the title, list the author’s first and last names, degree, affiliation, city, state, and country.
  • Separate multiple authors with a semicolon, and underline the primary author’s name (one primary author per abstract).
  • Use one blank line between the title and the body of the abstract and between paragraphs.
  • The abstract file name should follow this format: LastNameofprimary author_FirstWordOfTitle (e.g., Zucker_Effects).
• Please ensure that your abstract is the correct length and use 1-inch margins.
• Use of standard abbreviations is desirable (e.g., LUTS), as well as standard symbols for units of measure (e.g., kg, g, mg, mL, L, and %). Place any special or unusual abbreviations in parentheses after the full word the first time that it appears. Use numerals to indicate numbers except to begin sentences. Do not use subheadings (e.g., Methods, Results).
• Simple tables or graphs may be included; however, they must fit within the designated abstract space of one page.