Pancreatic Alpha-Cell Mathematical Models

Pancreatic alpha-cell mathematical models from our lab are listed below. Glucagon opposes the glucose-lowering actions of insulin and has become more widely appreciated as a contributing factor in type 2 diabetes. These models address the extent to which glucagon secretion is controlled by ion channels in the alpha cells and by paracrine secretion of insulin and somatostatin by pancreatic beta and delta cells, respectively. They also consider which ion channels are responsible.

View other models from our lab by subject on our Mathematical Models page. Visit to view a list of models by publication citation.

Paracrine Control of Glucagon Secretion (The BAD Model)

This model describes how alpha-cell electrical activity and glucagon secretion are regulated by paracrine hormones secreted by beta and delta cells. It also accounts for coordinated oscillations of glucagon, insulin and somatostatin.

Paracrine Regulation of Glucagon Secretion: The β-α-δ Model.
Ha J, Kimchi O, Sherman A, Watts M.
Am. J. Physiol. (Endocrinol. Metab.) (2016) 310:E597-E611. Abstract/Full Text
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Single-Cell Alpha Cell Model

This model describes intrinsic mechanisms for glucose to control glucagon secretion.

Modeling the pancreatic alpha-cell: Dual mechanisms of glucose suppression of glucagon secretion.
Sherman A, Watts M.
Biophys. J. (2014) 106:741-751 Abstract/Full Text
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Last Reviewed February 2024