We are investigating embryonic functions of microRNAs and mechanisms of microRNA turnover.

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A lncRNA drives developmentally timed decay of all members of an essential microRNA family.
Grimme AL, Li L, Scholl A, Donnelly BF, Channamraju N, Vieux KF, Zhou L, Seydoux G, Xie M, McJunkin K.
Genes Dev (2026 May 4) 40:737-755. Abstract/Full Text
A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family.
Sakhawala RM, Tirgar R, Vieux KF, Haskell D, Yu G, Zinovyeva A, McJunkin K.
Genes Dev (2025 Oct 1) 39:1198-1218. Abstract/Full Text
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Last Reviewed April 2025