Translational Research for Therapeutic Discovery and Development
As part of its mission to reduce the burden of disease, NIDDK participates in a series of notices of funding opportunities to encourage translation of basic discoveries into novel therapeutics. The diagram below illustrates a typical pipeline for the discovery and development of small molecules and non-viral biologics that modulate a target or phenotype of interest. Click on each stage to learn more about NIH funding opportunities and resources to support that aspect of therapeutic discovery and development. As a target and/or pre-therapeutic agent moves through this pipeline the goal is to continue to accumulate evidence that they will modify disease outcomes in clinical populations with an acceptable safety profile.
Target AssayScreeningHits and
HitHit to LeadLead Series