Translational Research: Assay Development
The identification and testing of agents acting through a particular target that may modify a disease’s course typically require a set of reliable and reproducible assays to demonstrate the efficacy, selectivity, and potency of the potential therapeutic candidate. Such assays may be used to identify hits from high throughput screening campaigns, refine peptides by molecular panning, or assess in vivo properties of agents.
Target AssayScreeningHits and
HitHit to LeadLead Series
NIDDK-Specific Funding Opportunities
PA-16-374, Assay Development and Screening to Discover Therapeutic or Imaging Agents for Diseases of Interest to the NIDDK (R01) has expired. The NIDDK is still interested in supporting this type of translational science and another potential option is to apply to the Parent R01 NOFO (PA-20-185) and request review assignment to the special emphasis panel PAR Panel: High Throughput Screening- ZRG1 BST-F 55, or another relevant review panel. Applicants should consult the NIH/CSR study section descriptions before requesting a specific review panel.
Please reach out to one of the Staff Contacts listed below if you have any questions.
- Academic Drug Discovery Consortium
- NIH Molecular Libraries and Imaging
- NIDDK Small Business Programs
Division of Kidney, Urologic, and Hematologic Diseases
Dr. Anna Sadusky
Division of Digestive Diseases and Nutrition
Dr. Bonnie Burgess-Beusse
Division of Diabetes, Endocrinology, and Metabolic Diseases
Dr. Yan Li