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Translational Research: Assay Development

The identification and testing of agents acting through a particular target that may modify a disease’s course typical require a set of reliable and reproducible assays to demonstrate the efficacy, selectivity, and potency of the potential therapeutic candidate. Such assays may be used to identify hits from high throughput screening campaigns, refine peptides by molecular panning, or assess in vivo properties of agents.

Starting Points
  1. Disease
    Biology
  2. Nominated
    Target
    Assay Development
    Screenable
    Assays
  3. Hit
    Hit to Lead
    Lead Series
  4. Lead
    Compound
    Lead
    Optimization
    Potential
    Therapeutic
    Leads
  5. Pre‑clinical
    Candidate
    Pre‑clinical
    Development
    Clinical
    Therapeutic
    Candidate
  6. Clinical
    Candidate
    Clinical
    Development
    Clinical Proof
    of Concept
  7. Licensing and
    Commercializa-
    tion Partners
    Market-ready
    Therapeutics
Outcomes and Resources

NIDDK-Specific Funding Opportunities

  • PA-16-374, Assay Development and Screening to Discover Therapeutic or Imaging Agents for Diseases of Interest to the NIDDK (R01)

Related Resources

Staff Contacts

For questions regarding this topic, please contact Dr. Aaron Pawlyk.