Genomics Core

John A. Hanover, Ph.D., Director
Harold Smith, Ph.D., Lead Scientist, sequencing services and bioinformatics

View staff and contact information.

The Genomics Core provides next-generation sequencing (NGS) on a fee-for-service basis to the NIH community, with priority for NIDDK users. Additional resources in support of this technology included consultation services, user-accessible instrumentation, bioinformatics infrastructure, and secure data management.

The facility offers next-generation (massively parallel) sequencing on the Illumina platform (HiSeq 3000, NextSeq 550, and MiSeq). Users provide libraries to the facility, and submit library information via the sample tracking website. Core personnel assess library quality, perform sequencing, assess data quality, and perform alignment. Data is returned to users by secure FTP. Front-end support includes assistance with experimental design and advice on library preparation. The facility houses a shared instrumentation laboratory and provides training for users. Instruments are available for sample shearing, automated chromatin immunoprecipitation, automated library construction, library quality assessment and purification, and real-time qPCR. Users also have access to integrated software packages for NGS data analysis. Additional bioinformatics support from Core personnel may be available on an ad hoc, collaborative basis.

NIH staff members are encouraged to contact Harold Smith or Ilhan Akan to discuss the application of facility services to their research programs, or to schedule a visit to the laboratory (located in Building 8, Room 1A11). The Genomics Core Facility was created in January 2003 to provide investigators with innovative, genome-scale technologies in gene expression and DNA sequencing.

For NIDDK Staff Only: Learn how to utilize the Core’s services.

Last Reviewed June 2023