Digestive Diseases Genetics & Genomics
Identifying genes that influence normal development, function, and diseases of the gastrointestinal tract.
The Digestive Diseases Genetics and Genomics program supports research to identify genes that influence normal development, function, and diseases of the gastrointestinal tract. It supports research to identify genes that influence disease and related anatomical and physiological traits, as well as research on patterns and regulation of gene expression associated with these traits. Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations. Typical research approaches include genome-wide association, exome and whole-genome sequencing, array- and sequencing-based studies of gene expression and epigenetic marks, integrated analyses of multi-omic (genomic, transcriptomic, proteomic, and metabolomic) data.
NIDDK Program Staff
- Bonnie Burgess-Beusse, Ph.D. Liver cell, molecular and developmental biology; liver regeneration, cell injury, repair, fibrosis and inflammation; bile, bilirubin and cholestasis
- Ludmila Pawlikowska, Ph.D. Genetics and Genomics of Liver and Gastrointestinal Diseases; Obesity and Nutrition
Recent Funding OpportunitiesView More Recent Funding Opportunities
Limited Competition for the NIDDK Short-Term Research Experience Program to Unlock Potential (STEP-UP) (R25 Clinical Trial Not Allowed)
Interventions for Stigma Reduction to Improve HIV/AIDS Prevention, Treatment and Care in Low- and Middle- Income Countries (R01 - Clinical Trial Optional)
HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)
Emergency Award: Novel Insights through Cross-Site Analyses of Existing RADx-UP Data (R21 Clinical Trial Not Allowed)
Emergency Award: RADx-UP Dissemination and Implementation (D and I) Research on COVID-19 Testing Interventions among Underserved and Vulnerable Populations (R01 Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.
Providing education and training for the next generation of biomedical and behavioral scientist
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NIH Common Fund
Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
Planning to Apply? Register Early
Registration is required at eRA Commons and grants.gov and can take 4 weeks.