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Cooperative Centers of Excellence in Hematology (CCEH)

Collaborative nonmalignant hematology research with innovative core resources backed by nationally recognized hematology expertise.

NIDDK Program Staff

  • Terry Rogers Bishop, Ph.D. Hematology; Stem Cells; Hematopoiesis; Globin; Hematology Centers and Training
  • Cindy N. Roy, Ph.D. Iron; Heme Biosynthesis; Terminal Erythropoiesis; Bone Marrow Failure/Myelodysplastic Syndrome; Systemic amyloidosis; Porphyrias

Funding for Molecular Hematology Centers

NIDDK funds Molecular Hematology Centers via U54.

Resources and Services Available from CCEH

The Cooperative Centers of Excellence in Hematology (CCEH) generate investigative resources that can be made available to the broader research community. They involve integrated teams of investigators from a wide range of disciplines, share specialized equipment, and serve as regional or national resources. The CCEH support pilot and feasibility programs that fund small projects aimed to generate preliminary data for inclusion in larger grant applications as well as short-term enrichment activities.

CCEH Centers

The CCEH provide a focus for multidisciplinary investigations into gene structure and function; the cellular and molecular mechanisms involved in the production, maturation, and function of blood cells; and the development of strategies to treat nonmalignant hematologic diseases. The CCEH offer unique resources and established hematology expertise through scientific cores on a fee-for-service basis. Each Center has independent opportunities for pilot and feasibility studies and for enrichment activities. The CCEH consortium is actively engaged to better serve the national hematology community, so check back often for new opportunities.

Center Sites

  • Fred Hutchison Cancer Research Center
    • Research Aims: To advance research in stem cell and transplantation biology.
    • Activities & Services
      • Large scale hematopoietic cell processing and repository, vector production, gene editing, clonal tracking, canine resource development, specialized mouse services
  • University of Utah
    • Research Aims: To advance research in iron and heme disorders.
    • Activities & Services
      • Iron and heme analysis, custom TALEN and CRISPR-Cas9 nucleases, metabolic profiling and isotope tracer analysis.
  • Indiana University - Purdue University at Indianapolis
    • Research Aims: To advance research in the regulation of human and murine hematopoiesis at the level of hematopoietic stem and progenitor cells.
    • Activities & Services
      • Experimental mouse resources, high resolution optical microscopy and imaging, angiogenesis, flow cytometry.
  • Yale School of Medicine
    • Research Aims: To apply innovative, emerging technologies to normal and perturbed hematopoiesis.
    • Activities & Services
      • Cell preparation and analysis, imaging, animal modeling.
  • Boston Children's Hospital
    • Research Aims: To provide state-of-the-art services for generating models of human hematologic disorders.
    • Activities & Services
      • Mouse embryonic stem cell and gene targeting, zebrafish, flow cytometry and epigenetics technology.

Related Links


Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

  • Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
  • NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
  • NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.

Additional Research Programs

Research Training

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NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.

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Diversity

Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.

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Small Business

Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.

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Human Subjects Research

Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.

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Translational Research

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NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.

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Meetings & Events

  • NIH Common Fund

    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.

  • Planning to Apply? Register Early

    Registration is required at eRA Commons and grants.gov and can take 4 weeks.