Gastrointestinal Physiology, Development, & Epithelial Biology
Basic, clinical, and translational research on GI development, diseases, and disorders.
The Gastrointestinal (GI) Physiology, Development, and Epithelial Biology program supports basic and translational research on the development, structure, and function of the GI tract in health and disease. This program focuses on GI development, regeneration, and healing, including the role of gastrointestinal stem cells and stem cell differentiation; basic biology of the GI epithelium, including studies on the structure and function of the epithelium, interactions between the epithelium and other components of the GI tract, and the integrity of the epithelium as a barrier; the cellular and molecular mechanisms regulating transport and absorption of water, ions, sugars, amino acids/peptides, lipids, vitamins, and minerals across the epithelium; requirements, bioavailability, and metabolism of nutrients and other dietary components at the organ, cellular, and subcellular levels in normal and diseased states; gut barrier function and permeability and normal and abnormal function of the enteric nervous system, including the structure and function of GI hormones peptides and bile acid metabolism. Also of interest are studies that explore the role of taste receptors in the GI tract in nutrient absorption and other metabolic functions.
NIDDK Program Staff
- Jose Serrano, M.D., Ph.D. Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis; Drug Induced Liver Injury; Clinical Research on GI Diseases
- Padma Maruvada, Ph.D. Nutrient Metabolism; Clinical Obesity and Nutrition
- Patricia Greenwel, Ph.D. Basic Neurogastroenterology; Gastrointestinal Development, Epithelial Biology, Stem Cell Biology
- Terez Shea-Donohue, Ph.D. Basic and Translational Neurogastroenterology, Gastrointestinal Motility, Gastrointestinal Barrier Function, Mucosal Immunology and Inflammation
Recent Funding OpportunitiesView More Recent Funding Opportunities
Limited Competition for the Continuation of Clinical Centers to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium (U01 Clinical Trial Optional)
Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24 Clinical Trial Optional)
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Toward ElucidAting MechanismS Contributing to HIV Reservoirs in NIDDK-relevant Tissues (Cure TEAMS) (R01 Clinical Trial Optional)
Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.
Providing education and training for the next generation of biomedical and behavioral scientist