Diabetic Kidney Disease
The mechanisms and pathophysiology underlying diabetic nephropathy and its progression.
The Diabetic Kidney Disease program advances basic research, natural history studies, and clinical trials. Fundamental research addresses the molecular pathogenesis of podocyte dysfunction, glomerulosclerosis and tubulointerstitial fibrosis. Also of interest are studies on the role of the renin-angiotensin system, growth factors, eicosanoids, intracelluar signalling pathways, and endothelial dysfunction. The portfolio aims to prevent, reverse, and ameliorate fibrosis. The program also advances studies on discovery of genes that protect people from or predispose them to diabetic nephropathy and identify early markers of increased risk for this disease.
NIDDK Program Staff
- Afshin Parsa, M.D., M.P.H. Chronic Kidney Disease; Kidney Genetics and Genomics
- Chris Ketchum, Ph.D. Basic Science; Renal Physiology
- Christine Maric-Bilkan, Ph.D. Basic Science PKD; Diabetic Kidney Disease; Sex and Gender Differences; Kidney and Urology Fellowships
- Paul L. Kimmel, M.D., M.A.C.P. Clinical AKI; Kidney Translational Genetics; Kidney Centers; Kidney HIV/AIDS
Recent Funding OpportunitiesView More Recent Funding Opportunities
Pilot and Feasibility Studies to Facilitate the Use of Diabetes Self-Management Education and Support to Improve Diabetes Care (R34 Clinical Trial Required)
Limited Competition: Revision to the Coordinating Center for Type 1 Diabetes TrialNet (U01 Clinical Trial Required)
Understanding and Reducing Cardiovascular Disease in Type 1 Diabetes Mellitus (R01 Clinical Trial Optional)
NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional)
NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required)
NIDDK carries forward the activities developed under NKDEP to meet ongoing need.
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.
Providing education and training for the next generation of biomedical and behavioral scientist