Diabetic Kidney Disease
The mechanisms and pathophysiology underlying diabetic nephropathy and its progression.
The Diabetic Kidney Disease program advances basic research, natural history studies, and clinical trials. Fundamental research addresses the molecular pathogenesis of podocyte dysfunction, glomerulosclerosis and tubulointerstitial fibrosis. Also of interest are studies on the role of the renin-angiotensin system, growth factors, eicosanoids, and intracelluar signalling pathways, as well as, causes and effects of renal endothelial cell dysfunction. The portfolio aims to prevent, reverse, and ameliorate fibrosis. Specific projects include studies that investigate the mechanisms of fibrosis and use of noninvasive techniques to detect and assess fibrosis (or its severity). The program also advances studies on discovery of genes that protect people from or predispose them to diabetic nephropathy and identify early markers of increased risk for this disease.
NIDDK Program Staff
Recent Funding OpportunitiesView More Recent Funding Opportunities
NIDDK Education Program Grants (R25 Clinical Trial Not Allowed)
Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial Not Allowed)
Diabetes Research Centers (P30)
Understanding the Glycemic Profile of Pregnancy - Clinical Centers (U01 Clinical Trial Not Allowed)
Understanding the Glycemic Profile of Pregnancy - Biostatistics Research Center (U01 Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities