Translational & Basic Liver Disease Research
Translational and basic research on liver physiology and pathophysiology and liver diseases.
The Translational and Basic Liver Disease Research program supports a wide range of scientific proposals that cover broad topics, such as cellular and molecular biology of the liver; developmental biology and regeneration of the liver; bile and bilirubin physiology and pathogenesis of cholestasis; liver cell injury, drug-induced liver injury (DILI), repair, and fibrosis; inflammation of the liver; and liver bioengineering and imaging. Furthermore, disease-specific proposals that improve the understanding of pathophysiological mechanisms and treatment of specific liver diseases or liver conditions are also supported by this research program.
NIDDK Program Staff
- Averell H. Sherker, M.D., FRCPC Autoimmune Liver Disease; Acute Liver Failure; Complications of Chronic Liver Disease; Gallbladder and Biliary Diseases; Liver Bioengineering and Biotechnology; Liver Cancer; Liver Transplantation
- Bonnie Burgess-Beusse, Ph.D. Liver cell, molecular and developmental biology; liver regeneration, cell injury, repair, fibrosis and inflammation; bile, bilirubin and cholestasis
- Edward Doo, M.D. Fatty Liver Disease; Genetic Liver Disease; HIV and Liver; Pediatric Liver Disease; Viral Hepatitis and Infectious Diseases
- Jose Serrano, M.D., Ph.D. Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis; Drug Induced Liver Injury; Clinical Research on GI Diseases
Recent Funding OpportunitiesView More Recent Funding Opportunities
HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
Advancing Gender Inclusive Excellence (AGIE) Coordinating Center (U54 Clinical Trial Not Allowed)
HEAL Initiative: Interdisciplinary Teams to Elucidate the Mechanisms of Device-Based Pain Relief (RM1 Clinical Trial Optional)
Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center and Database (UM1 Clinical Trial Not Allowed)
Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
This online resource provides information on drug-induced liver injury resulting from prescription medications, over-the-counter drugs, and complementary and alternative medicines such as herbals and dietary supplements.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities