Nutrient Metabolism, Status, & Assessment
Basic, clinical, and translational research on the requirements, bioavailability, and metabolism of nutrients and other dietary components.
The Nutrient Metabolism, Status, and Assessment program supports basic and clinical studies related to the absorption, metabolism, bioavailability, and requirements of nutrients and other dietary components. This includes research on processes at the organ, cellular, and subcellular levels in normal and diseased states. Suitable studies include those that explore how the nutritional status of an organism, such as over-nutrition and under-nutrition, affects physiological and metabolic functions contributing to the pathophysiology of diseases of interest to the NIDDK. Specific areas of interest include the role of gut-brain signals in nutrient sensing; mechanisms of action/interaction of nutrients within the body; the process of food digestion in the gastrointestinal tract; and the absorption and transport of water, ions, sugars, amino acids/peptides, lipids, vitamins, minerals, and other macromolecules and bioactive components. Other supported studies include those that explore modifications of nutrient metabolism and/or status due to genetic variation, altered gut barrier function, and/or in response to stress, circadian and diurnal variations, drug use, toxicants, bariatric surgery and physical activity in health and disease. The program also supports studies that explore how dietary modifications affect gene regulation and expression at the transcriptional, translational, epigenetic, and functional level, including relevant nutrigenetic and nutrigenomic approaches.
Appropriate studies explore the impact of dietary modification on the human gut microbiome and/or dysregulation of gut microbiome on nutrient absorption, gut barrier function, and permeability and metabolism. Mechanistic studies that explore the role of prebiotic and probiotic metabolism on microbiome compositional and functional changes and host physiology are also appropriate.
This program also supports studies that explore mathematical models contributing to the understanding of whole-body energy balance and metabolism, and of metabolic fluxes in cells, tissues, and organs. A particular focus of interest is on models that allow the integration of data gained from a variety of technological approaches, such as tracer studies, calorimetry, plasma hormone/cytokines, metabolomics, genomics, epigenomics, and proteomics, and on those models that would be of clinical utility, including prediction of plasma glucose levels in diabetes, nutritional partitioning, nutritional status, and weight management.
The program supports research on specific metabolic considerations related to alternative forms of nutrient delivery and use, such as total parenteral and enteral nutrition. Other supported studies involve research for improving methods to determine dietary intake and compliance, including dietary recall methodologies and questionnaires; novel approaches for collecting information on dietary intake, identification and development of biomarkers of intake and exposure; and the development of methods and assays for assessing nutritional status and for determining specific nutritional requirements in health and disease.
NIDDK Program Staff
Recent Funding OpportunitiesView More Recent Funding Opportunities
Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)
Launching Future Leaders in Global Health (LAUNCH) Research Training Program (D43 Clinical Trial Optional)
NIDDK Short-Term Research Experience Program to Unlock Potential (STEP-UP) (R25 Clinical Trial Not Allowed)
Emergency Awards: Community-engaged COVID-19 Testing Interventions among Underserved and Vulnerable Populations RADx-UP Phase II (U01 Clinical Trial Optional)
Emergency Award: RADx-UP - Social, Ethical, and Behavioral Implications (SEBI) Research on Disparities in COVID-19 Testing among Underserved and Vulnerable Populations (U01 Clinical Trials Optional)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.