Pancreas Basic Research & Development
Research on the development, structure, function, and diseases of the exocrine pancreas.
The Pancreas Basic Research and Development program supports research on the structure, function, and diseases—excluding cancer and cystic fibrosis—of the exocrine pancreas. Specific projects examine the hormonal and neural regulation of electrolyte, fluid, and enzyme secretion; receptors for secretagogues; and stimulus-secretion coupling mechanisms. Also of interest are studies of gut-islet-acinar interrelations; organization and expression of pancreatic genes; and protein synthesis and export.
The program encourages work that advances our understanding of tissue injury, repair, and regeneration; the physiology and pathology of trophic responses; neural innervation; and transcapillary solute and fluid exchange. Information about pancreatic development has led to insights regarding nuclear transcription factors and signaling pathways regulating pancreatic progenitor/precursor cell expansion and differentiation. The identification and characterization of progenitor cells that can support expansion of ductal/exocrine cell populations destroyed during acute or chronic pancreatitis, or pancreatic cancer, and factors that control differentiation of the descendants of these progenitors--along with a more complete understanding of the normal pancreas at each stage of development--is essential for future advances in detecting, preventing, and treating these diseases.
NIDDK Program Staff
- Jose Serrano, M.D., Ph.D. Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis; Drug Induced Liver Injury; Clinical Research on GI Diseases
Recent Funding OpportunitiesView More Recent Funding Opportunities
HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional)
Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)
High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional)
Analysis, Technology, Leadership, Administration and Science (ATLAS) Center (U24 Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
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