Primary Biliary Cholangitis (Primary Biliary Cirrhosis)

Primary biliary cholangitis is a chronic disease in which the small bile ducts in the liver become injured and inflamed and are eventually destroyed. When there are no bile ducts, bile builds up and causes liver damage.

Common early symptoms of primary biliary cholangitis are feeling tired and having itchy skin. Many people have no symptoms when they are first diagnosed. Experts aren’t sure what causes primary biliary cholangitis, but genes and environmental triggers may play a role.

Primary biliary cholangitis is a chronic disease in which the small bile ducts in the liver become injured and inflamed and are eventually destroyed. When there are no bile ducts, bile builds up and causes liver damage.

Doctors treat primary biliary cholangitis with medicines. Doctors may treat the symptoms and complications of the disease with medicines, dietary supplements, changes in diet and lifestyle, and medical procedures.

A healthy, well-balanced diet is important in all stages of primary biliary cholangitis. Your doctor can recommend a healthy eating plan that provides enough calories and nutrients to help your liver work properly and manage complications.

The NIDDK conducts and supports clinical trials in many diseases and conditions, including liver diseases. The trials look to find new ways to prevent, detect, or treat disease and improve quality of life.