Acute & Chronic Pancreatitis
Research on the etiology and pathogenesis of acute and chronic pancreatitis.
Pancreatitis is a syndrome that is characterized by pain associated with inflammation and damage to the pancreas. Relapsing or chronic pancreatitis can lead to exocrine and endocrine pancreatic insufficiency. Major causes of pancreatitis are alcohol use, cholelithiasis, drug toxicity, and infections. In some cases there may be a genetic basis; however, a significant percentage of cases are idiopathic.
The Acute and Chronic Pancreatitis program supports a broad range of research topics on the etiology and pathogenesis of acute and chronic pancreatitis. Some examples are: the elucidation of mechanisms by which alcohol and drugs induce or promote premature activation of pancreatic enzymes (zymogens) within the pancreas directly or indirectly; the determination of the role of diet, including fat and protein, in the modulation of gene expression and synthesis of various secretagogues; the roles of cytokines, chemokines, adhesion molecules, and inflammatory leukocytes in the initiation and progression of inflammation of the pancreas; the characterization of the molecular mechanisms of pancreatic stellate cell activation leading to increased deposition of extracellular matrix proteins and fibrosis; the characterization of the relationship between pancreatitis, diabetes, obesity, and pancreatic cancer; and the identification and characterization of biomarkers of early cell or tissue perturbation that can be used for diagnosis of the disease.
NIDDK Program Staff
Recent Funding OpportunitiesView More Recent Funding Opportunities
Limited Competition for the Continuation of Clinical Centers to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium (U01 Clinical Trial Optional)
Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24 Clinical Trial Optional)
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Toward ElucidAting MechanismS Contributing to HIV Reservoirs in NIDDK-relevant Tissues (Cure TEAMS) (R01 Clinical Trial Optional)
Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)
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