Metabolism, Energy Balance & Obesity
Basic and clinical studies related to energy balance and physiological mechanisms modulating weight gain, loss and maintenance.
The Metabolism, Energy Balance, and Obesity program supports basic and clinical studies related to energy balance and physiological mechanisms modulating weight gain, loss, and maintenance. Specific areas of interest include factors that affect energy regulation such as food choices, diet composition, food intake, eating behavior, appetite, satiety, body composition, nutrient partitioning, sedentary behavior, and physical activity. Other supported research topics include, but are not limited to, hormonal regulation of body composition, such as interactions between nutrition, exercise, thermic effect of food and appetite-regulating hormones; circulating factors and their receptors involved in regulatory pathways controlling feeding behavior, satiety, energy expenditure and thermogenesis; interactions between the gut-brain axis and peripheral secretory metabolic signals (e.g., insulin, leptin, glucocorticoids, ghrelin, and other small bioactive peptides); integration of appetite-regulating and metabolic signals in the regulation of food intake and energy balance; obesity associated inflammation; the impact of circadian rhythms on nutrient sensing and food intake; and the impact of gustatory signals on food consumption and energy balance. Studies investigating the mechanism by which interventions, including drugs, devices, and surgery, affect food consumption or food preferences, physical activity, body composition, or other aspects of energy regulation are also supported by this program.
Also of interest are studies that use improved methods to assess body composition, examine health-risk factors with specific degrees of obesity or body composition, and determine the effects of exercise on body composition.
This program also supports studies that explore mathematical models contributing to the understanding of whole-body energy balance and metabolism as well as the metabolic pathways in cells, tissues, and organs. A particular focus of interest is on models that allow the integration of data gained from a variety of technical approaches, such as tracer studies, calorimetry, plasma hormone/cytokines, metabolomics, genomics, epigenomics, and proteomics, and on those models that would be of clinical utility, including prediction of plasma glucose levels in diabetes, nutritional partitioning, and weight management.
NIDDK Program Staff
- Carol Renfrew Haft, Ph.D. Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic disease
- Corinne M. Silva, Ph.D. Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease
- James F. Hyde, Ph.D. Neurobiology of energy balance and body composition in obesity; Diabetes Research Centers
- Karen L. Teff, Ph.D. Effects of bariatric surgery on diabetes and metabolism, clinical and basic science of hepatic metabolism and hypoglycemia, human sleep and diabetes
- Luke E Stoeckel, Ph.D. Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications
- Maren Laughlin, Ph.D. Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic disease
- Padma Maruvada, Ph.D. Nutrient Metabolism; Clinical Obesity and Nutrition
- Stavroula K. Osganian, M.D., Sc.D., M.P.H. Pediatric Clinical Obesity
- Susan Z. Yanovski, M.D. Obesity and Eating Disorders
- Xujing Wang, Ph.D. Data science; computation modeling; integrative genomics; network biology; genotype-phenotype relationship
Recent Funding OpportunitiesView More Recent Funding Opportunities
Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of Novel Tools and Methodologies (RC2 Clinical Trial Optional)
New Paradigms in Tissue Communication-from mediators to metabolic function (RC2 Clinical Trials Optional)
Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional)
Regenerative Medicine Innovation Projects (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required)
Regenerative Medicine Innovation Projects (RMIP) (UT2 - Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities