Diabetes Genetics & Genomics
Genetic mechanisms underlying type 1 and type 2 diabetes and how genetic and epigenetic variation influences the metabolism of therapeutics.
The Diabetes Genetics and Genomics program advances research to identify the genes and intergenic regions that predispose to or protect from developing type 1 or type 2 diabetes. In addition, research to define mechanisms underlying disease risk associated with genetic and genomic variation is also encouraged. By determining the genetic mechanisms underlying these diseases — and how genetic and epigenetic variation influence therapeutics — researchers should be able to develop better therapeutics and prevention strategies. Studies can involve the use of animal models to identify the genes responsible for development of or protection from the disease; research to develop genetic resources; creation of animal models for therapeutic trials; quantitative statistical and genetic methods to identify diabetes genes in human populations; investigation of the interactions of multiple genes and environmental factors; studies that determine genetic differences between populations that result in health disparities; and research to examine the genetics underlying variation in response to diabetes drugs.
NIDDK Program Staff
- Beena Akolkar, Ph.D. Clinical research in the prevention and immunopathogenesis of Type 1 Diabetes and the genetics and genomics of Type 1 and Type 2 Diabetes
- Yan Li, Ph.D. Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and precision medicine.
- Norann Zaghloul, Ph.D. Genetics and genomics of Type 2 diabetes and functional genomic studies in Type 2 diabetes and metabolic diseases
- Xujing Wang, Ph.D. Data science; computation modeling; integrative genomics; network biology; genotype-phenotype relationship
Recent Funding OpportunitiesView More Recent Funding Opportunities
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes Biostatistics Research Center (U01 Clinical Trial Not Allowed)
Continuation of The Collaborative Islet Transplantation Registry (U01 Clinical Trial Not Allowed)
Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required)
PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.