Endocrinology & Hormone Signaling
Endocrinology, neuroendocrinology, hormone signaling, nutrient sensing, the Hypothalamic-Pituitary- Axis, and bone metabolism.
The Endocrinology and Hormone Signaling program supports basic and clinical research on endocrinology, neuroendocrinology, hormone signaling, and nutrient sensing—with an emphasis on developing mechanistic insights into diabetes, obesity, and other endocrine-related health problems. Studies include those that address the regulation of body composition; interactions between nutrition, exercise, and anabolic hormones; neural pathways and neuropeptides that regulate feeding behavior, satiety, and energy expenditure; the function and interaction of the hypothalamic-pituitary axis with peripheral metabolic signals; and the hormonal regulation of bone and mineral metabolism in health and disease. Other studies address the structure and function of nuclear receptors and co-regulators and their regulation of gene expression; cellular mechanisms of glucose regulation; the intracellular signals that regulate cellular responses to insulin and other hormones; and the mechanisms and signaling pathways involved in nutrient sensing. These studies are aimed at demonstrating how disruption of the pathways leads to the onset and/or progression of metabolic disease.
NIDDK Program Staff
- Carol Renfrew Haft, Ph.D. Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic disease
- Corinne M. Silva, Ph.D. Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease
- James F. Hyde, Ph.D. Neurobiology of energy balance and body composition in obesity; Diabetes Research Centers
- Saul Malozowski, M.D., Ph.D., M.B.A. Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism
Recent Funding OpportunitiesView More Recent Funding Opportunities
Advanced Clinical Trials to test Artificial Pancreas Device Systems in Type 1 Diabetes (U01 Clinical Trial Required)
Mass Spectrometric Assays for the Reliable and Reproducible Detection of Proteins/Peptides of Importance in Obesity Research (U01 Clinical Trial Not Allowed)
Establishing a Cohort to Clarify Risk and Protective Factors for Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) - Planning Cooperative Agreements (U34 Clinical Trial Not Allowed)
Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/44 Clinical Trial Not Allowed)
Type 1 Diabetes TrialNet Clinical Network Hub (U01 Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities