Endocrinology & Hormone Signaling
Endocrinology, neuroendocrinology, hormone signaling, nutrient sensing, the Hypothalamic-Pituitary- Axis, and bone metabolism.
The Endocrinology and Hormone Signaling program supports basic and clinical research on endocrinology, neuroendocrinology, hormone signaling, and nutrient sensing—with an emphasis on developing mechanistic insights into diabetes, obesity, and other endocrine-related health problems. Studies include those that address the regulation of body composition; interactions between nutrition, exercise, and anabolic hormones; neural pathways and neuropeptides that regulate feeding behavior, satiety, and energy expenditure; the function and interaction of the hypothalamic-pituitary axes with peripheral metabolic signals; and the hormonal regulation of bone and mineral metabolism in health and disease. Other studies address the cellular mechanisms of glucose regulation; the intracellular signals that regulate cellular responses to insulin and other hormones; and the mechanisms and signaling pathways involved in nutrient sensing as well as the integration of circadian rhythms and metabolic pathways.
NIDDK Program Staff
- Henry B. Burch, M.D. Clinical studies utilizing existing digital health technology for the prevention and treatment of type 2 diabetes, clinical and basic science studies involving non-neoplastic disorders of the thyroid, clinical studies involving medical and novel dietary treatment of type 2 diabetes.
- Brad Cooke, Ph.D. Developmental Neuroendocrinology, Electrophysiology, and Cognitive Neuroscience
- Carol Renfrew Haft, Ph.D. Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic disease
- Saul Malozowski, M.D., Ph.D., M.B.A. Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism; HIV/AIDS-associated metabolic and endocrine dysfunction
- Corinne M. Silva, Ph.D. Signaling pathways, nutrient sensing and circadian rhythms in metabolic diseases; role of intrauterine environment in offspring metabolic disease; Diabetes Research Centers
Recent Funding OpportunitiesView More Recent Funding Opportunities
Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)
Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)
Pilot and Feasibility Trials on the Integration of Social and Medical Care for Type 1 Diabetes Mellitus (R01 Clinical Trial Required)
Small Grants to Enhance the Use of the All of Us Research Programs Data (R03 Clinical Trial Not Allowed)
Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Independent Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.